Abnormal lateralization of functional connectivity between language and default mode regions in autism

نویسندگان

  • Jared A Nielsen
  • Brandon A Zielinski
  • P Thomas Fletcher
  • Andrew L Alexander
  • Nicholas Lange
  • Erin D Bigler
  • Janet E Lainhart
  • Jeffrey S Anderson
چکیده

BACKGROUND Lateralization of brain structure and function occurs in typical development, and abnormal lateralization is present in various neuropsychiatric disorders. Autism is characterized by a lack of left lateralization in structure and function of regions involved in language, such as Broca and Wernicke areas. METHODS Using functional connectivity magnetic resonance imaging from a large publicly available sample (n = 964), we tested whether abnormal functional lateralization in autism exists preferentially in language regions or in a more diffuse pattern across networks of lateralized brain regions. RESULTS The autism group exhibited significantly reduced left lateralization in a few connections involving language regions and regions from the default mode network, but results were not significant throughout left- and right-lateralized networks. There is a trend that suggests the lack of left lateralization in a connection involving Wernicke area and the posterior cingulate cortex associates with more severe autism. CONCLUSIONS Abnormal language lateralization in autism may be due to abnormal language development rather than to a deficit in hemispheric specialization of the entire brain.

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عنوان ژورنال:

دوره 5  شماره 

صفحات  -

تاریخ انتشار 2014